Sistema Regional de Información
en línea para Revistas Científicas de América Latina,
el Caribe, España y Portugal

Background: follicular non-Hodgkin's lymphoma occupies the second place among non-Hodgkin's lymphomas of line B, they are characterized by a pattern of continuous remissions and relapses. Fludarabine constitutes a treatment option for the same as it achieves a rapid remission, with a decrease in the percentage of relapse. Objective: to evaluate fludarabine as a rescue treatment for follicular non-Hodgkin lymphoma. Methods: a concurrent prospective longitudinal, analytical, observational cohort study was conducted. The study universe was made up of patients who attended the Hematology consultation with a diagnosis of follicular non-Hodgkin's lymphoma and consisted of 63 patients, of which 21 were selected by intentional non-probabilistic sampling who received treatment with fludarabine, made up a cohort of exposed, these were compared with 42 patients with similar characteristics who received other poly-chemotherapy regimens that did not include fludarabine and they constituted the unexposed cohort. Results: the number of male patients over 50 years of age, belonging to Cotswold stage IV, and those with a low-intermediate risk of relapse was greater. The disease-free survival time was longer in those treated with fludarabine, who had fewer complications. Conclusions: in patients treated with fludarabine as rescue treatment for follicular lymphoma, the disease-free survival time was longer and there were fewer complications, which show its usefulness as a first-line treatment in the absence of rituximab. DeCS: LYMPHOMA, NON-HODGKIN/drug therapy; LYMPHOMA, NON-HODGKIN/therapy; LYMPHOMA, FOLLICULAR/diagnosis; RECURRENCE; OBSERVATIONAL STUDY.

Background: Crohn's disease is characterized by segmental granulomatous inflammation of the intestinal tract and usually affects the cutaneous tissues. Its development includes the complex interaction between genetic predisposition, exposure to the environment, dysfunction of the epithelial barrier and the abnormal immune response to pathogenic and commensal bacteria. The specific lesions of the disease are extra-intestinal manifestations, the most common: oral aphthae and perianal fistulas. Objective: to report a case with fistulizing perianal Crohn's disease. Case report: 42-year-old male patient, white; with a history of having been treated since 2006 for recurrent aphthous stomatitis. He arrives at the Manuel Ascunce Domenech University Hospital for the first time in 2013, where he was evaluated and followed by the Coloproctology service. Conclusions: an evolutionary colonoscopy and biopsy was performed, it was suspected by the symptoms in Crohn's disease with perianal localization. DeCS: CROHN DISEASE; RECTAL FISTULA; INFLAMMATORY BOWEL DISEASES/etiology; COLONOSCOPY; CASE REPORTS.

Background: the duodenum corresponds to the second location where the gastrointestinal diverticula are most frequently presented after the colon. Lemmel's syndrome, also known as intermittent obstructive jaundice, presence of duodenal diverticula near the papilla of Vater could favor the development of pancreatic biliary diseases. Objective: to present the case of an older adult with jaundice in mucosa and intermittent skin associated with febrile episodes not quantified and pain in the right hypochondrium. Case report: a 67-year-old female patient with an obstructive jaundice syndrome, without the presence of choledocholithiasis or other alteration of the biliary tree other than the presence of a duodenal diverticulum. For this symptomatology is referred to Gastroenterology consultation. Conclusions: Lemmel's syndrome is a rare pathology that must be taken into account as a cause of obstructive jaundice. DeCS: JAUNDICE, OBSTRUCTIVE/diagnosis; JAUNDICE, OBSTRUCTIVE /pathology; DIVERTICULUM, STOMACH; AMPULLA OF VATER; CASE REPORTS.

Background: human parvovirus B19 is the causative agent of fifth disease in children and of polyarthropathy and acute erythroblastopenia in adults. Objective: to determine the clinical, epidemiological and analytical aspects of parvovirus B19 infection during a nosocomial outbreak. Methods: a descriptive cross-sectional study was carried out in the Medicine and Pediatrics services of the Regional Lambayeque Hospital during the months of November and December 2017. A study of a series of cases was carried out based on the patients and health personnel historical charts, with a positive result to the PVB1 infection, through the ELISA technique. The universe was constituted by 153 patients treated in the Medicine and Pediatrics services. Of which it was selected a sample of 16 cases, based on the criteria. Results: 16 positive patients from the Medicine and Pediatrics departments were identified, with IgM titers against parvovirus B19 greater than 17 IU / mL, whose ages ranged from 6 months to 38 years. Among them 8/16 patients presented comorbidities of which 3/8 corresponded to autoimmune diseases. In-hospital contacts were evident in both services. Greater morbidity was found in middle-aged female health personnel. Conclusions: Parvovirus B19 infection in the hospital or other health environment represents a risk mainly for health personnel. DeCS: DISEASE OUTBREAKS/prevention&control; PARVOVIRIDAE INFECTIONS/epidemiology; PARVOVIRIDAE INFECTIONS/transmission; PARVOVIRUS B19, HUMAN; HEALTH PERSONNEL.

Fundamento: debido a las características de la infección con SARSCoV-2, la cavidad bucal es un entorno que representa un alto riesgo para producir infección cruzada entre los pacientes y los odontólogos. Objetivo: recopilar la evidencia científica sobre si la cavidad bucal es una fuente de transmisión del SARSCoV-2. Métodos: se realizó una revisión en PubMed/Medline y Cochrane mediante términos de indización, para obtener información si la cavidad bucal es una fuente de transmisión del SARSCoV-2. Resultados: debido al contacto cercano con la boca y la nariz del paciente, las gotas y los aerosoles producidos en el tratamiento bucal exponen al odontólogo a infectarse con SARSCoV-2. Al analizar la información bibliográfica se encuentra evidencia de que el SARSCoV-2 se une de forma inicial a la enzima convertidora de angiotensina II que se encuentra en la mucosa oral, la lengua y las glándulas salivales, para después recién colonizar los tractos respiratorios; por lo que, se puede considerar a la cavidad bucal como una fuente de contagio y además la saliva puede usarse para realizar el análisis molecular del SARSCoV-2. Conclusiones: la evidencia científica recopilada, sugiere que la cavidad bucal puede actuar como una fuente de contagio del SARSCoV-2, gracias a la presencia en la boca de la enzima convertidora de angiotensina II que actúa como receptor del SARSCoV-2 y convierte a esta cavidad en una fuente de transmisión. DeCS: INFECCIONES POR CORONAVIRUS/epidemiología; INFECCIONES POR CORONAVIRUS/virología; INFECCIONES POR CORONAVIRUS/transmisión; VIRUS DEL SARS/patogenicidad; SALIVA/virología.

Background: the peripheral blood extension or peripheral lamina, as it is also known, is the semi-quantitative morphological evaluation of the three hematopoietic series, in an extension of peripheral blood colored and observed through the microscope. Objective: to develop a methodological procedure for the extension of peripheral blood from an interdisciplinary perspective in the degree in Clinical Bioanalysis. Methods: cross-sectional descriptive study in the period from September to November 2018, in the Technological Faculty belonging to the University of Medical Sciences of Camagüey. Theoretical methods such as analysis and synthesis and inductive and deductive methods were used. Of the empirical methods, the analysis of documents, the exploratory diagnostic test, results of controls to classes, the interview and survey for the validation of the proposal were applied. Results: insufficiencies regarding the establishment of interdisciplinary relationships between the contents of Histology and the hematological component of the Laboratory Diagnostic subject I, the students showed difficulties in performing the technique and failed to characterize morphologically some of the hematopoietic cells. Conclusions: a methodological procedure was developed for the peripheral lamina technique from an interdisciplinary perspective and the validation of the proposal by means of the consensus method formed by a nominal group where the categories of very adequate and suitable for the development of the peripheral lamina technique result. The observation of extension peripherals is an important element in the orientation of the analysis of the different diseases, an essential component of the integral diagnosis of the clinical laboratory. DeCS: CLINICAL LABORATORY TECHNIQUES; BLOOD CELL COUNT/methods; LABORATORY PERSONNEL/education; BLOOD SPECIMEN COLLECTION/methods; HEMATOLOGIC TESTS/methods.

Background: Background: videolaparoscopic cholangiography has become a diagnostic and therapeutic method in choledocholithiasis. Objective: to evaluate the value of transcystic cholangiography in patients with suspected choledocholithiasis. Methods: an analytical study was carried out to interpret and verify the result with the objective of analyzing the correspondence between suspected choledocolithiasis and the result of translastic videolaparoscopic cholangiography, at the Octavio Teaching Surgical Clinical Military Hospital of La Concepción de la Pedraja, since April, 2012 to December, 2018. The sample consisted of 62 patients with suspected choledocolithiasis. Results: in the study, moderate suspicion of choledocholithiasis prevailed in the female sex at the expense of ultrasound and laboratory studies, specifically the increase in the value of alkaline phosphatase and dilation of the common bile duct between 8 and 10 millimeters. The most frequent results of the procedure were; the main bile duct without alterations and vesicular adhesions. The procedure extended for more than 60 minutes in more than half of the cases. The hospital stay after the procedure was less than three days and an excellent result prevailed. Conclusions: women have a higher index of suspicion of choledocholithiasis and in a moderate range. Laboratory and ultrasound criteria prevail in these patients, however, they are not specific to choledocholithiasis. The main bile duct without alterations and vesicular adhesions are the most frequent results during the procedure. The average surgical time in this procedure is more than 60 minutes. The hospital stay after proceeding is usually less than three days. The final result with this procedure is excellent. DeCS: CHOLEDOCHOLITHIASIS/diagnostic imaging; CHOLANGIOGRAPHY; MINIMALLY INVASIVE SURGICAL PROCEDURES; VIDEO-ASSISTED SURGERY; ANALYTICAL EPIDEMIOLOGY.

Background: hand hygiene is the most important factor for self-care, it is one of the most economical and effective ways to prevent diseases such as cholera, typhoid fever, acute respiratory diseases and other gastrointestinal tract infections. Objective: to perform a journey through the history of handwashing. Methods: a bibliographic review was carried out, a search without language restrictions from 2008 to 2019, and following a chronological order in the analysis. The search terms hand hygiene, communicable diseases, and health care, were used in the SciELO, Ebsco, LILAC, and MEDLINE databases. 94 published documents were identified, of which 35 were selected according to the objective. Development: we refer to the biographical background of Ignaz Philipp Semmelweis, and to the history of hand washing in Cuba and the need to comply with hand washing in hospitals. We provide information on the promotion of proper hand hygiene to reduce the risk of contracting communicable diseases. Conclusions: the promotion of adequate hand hygiene reduces the risk of contracting communicable diseases. By providing care with safe hands a quality service is offered that preserves patient safety in all areas. DeCS: SELF CARE; HAND DESINFECTION/methods; DISEASE OUTBREAKS/prevention & control; HEALTH PROMOTION; REVIEW.