Sistema Regional de Información
en línea para Revistas Científicas de América Latina,
el Caribe, España y Portugal

Lung cancer is one of the tumors that have the ability to metastasize in the brain and have the ability to penetrate the blood-brain barrier, the clinic is varied depending on the affected site, as well as the associated risks of convulsion. Therefore, the choice of treatment is complex, considering the primary, the number of metastases and the affected sites. Radiation therapy has long been the choice of patients who are not candidates for surgery, the presence of mutations have allowed to provide targeted therapies such as tyrosine kinase inhibitors that penetrate the blood-brain barrier and have been key to therapeutic management.   DOI 10.25176/RFMH.v19.n1.1798

Condyloma acuminatum is a sexually transmitted disease caused by the papilloma virus(HPV) It is frequently found in the ano-genital region and is uncommon in the oral cavity.However, the increase in oral sexual activity has further favored the appearance of HPV in theoral mucosa. This report describes a condyloma in the oral cavity (tongue) of a 43-year-old man withhistory of oral sexual practice, whose diagnosis was confirmed by a biopsy.   DOI 10.25176/RFMH.v19.n1.1799

The Doctor Honoris Causa, is the highest honorary title granted by the Ricardo Palma University, to eminent persons. They are conferred with zeal by our house of studies to very outstanding personalities of the national and international scope, who with their work and personal trajectory honor to the culture, the science and the humanity.I want to thank the Rector of the University for receiving the order, to make a brief sketch of Dr. Alfredo Quiñones Hinojosa. DOI:10.25176/RFMH.v19.n2.2003

Introduction: The lymphocyte / monocyte index (ILM) has been described as an inflamatory prognostic parameter in many hematological diseases and solid tumors. The aim of the present study was to evaluate the prognostic value of the lymphocyte / monocyte index in the survival of patients with diffuse large B-cell lymphoma (LCGBD). Methods: The present is an analytical, longitudinal and non-experimental study. Patients diagnosed with diffuse large B-cell lymphoma of the Edgardo Rebagliati Martins hospital from 2010 to 2017 were selected. Results: 121 patients were included, 57% female, 66.1% older than 60 years. Regarding the Performance Status Zubrod, 66.5% corresponded to the degree of best forecast 0 and 1; 59.5% presented associated B symptoms. Nearly 60% were stages I and II and 57% presented extranodal involvement. We show that the ILM is significant for overall survival in the regression analysis of bivariate cox, not reaching significance in the multivariate. Conclusion: ILM is a potential simple and accessible prognostic biomarker for our population with diffuse large B-cell lymphoma. DOI:10.25176/RFMH.v19.n2.2068

Objective: Compare the values of the blood biomakers: uric acid, creatinine, glucose, cholesterol and triglycerides, in two groups of university professors apparently healthy. Methods: The first group, formed by 58 professors aged 60 to 64, and the second formed by 35 professors aged 75 to 81, in order to evaluate if there is a significant statistic difference in both groups. Results: The values of uric acid in group I were between 2,50 mg/dL. and 8,20 mg/dL; in groups II were between 2,50 mg/dL and 8,63 mg/dL, showing a significant difference (p=0.035). The values of creatinine in group I were between 0,64 mg/dL and 1,56 mg/dL; and in group II were between 0,80 mg/dL and 1,61 mg/dL., showing a significant difference (p=0.004). The values of glucose in group I were between 63 mg/dL and 188 mg/dL; and in group II were between 60 mg/dL y 297 mg/dL, not showing significant difference (p=0.671). The values of cholesterol in group I were between 125 mg/dL and 265 mg/dL; and in group II were between 107 mg/dL and 244 mg/dL; not showing significant difference (p=0.053). The values of triglycerides in group I were between 58 mg/dL and 507 mg/dL; and in group II were between 68 mg/dL and 314 mg/dL; not showing significant difference (p=0.104). Conclusion: There is a significant difference in the biomarkers of uric acid and creatinine between the age groups; however, there was not found significant difference in the biomarkers of glucose, cholesterol and triglycerides between the age groups. DOI:10.25176/RFMH.v19.n2.2063

Introduction: The cervical clearance is the precursor lesion of cancer of the cervix, in which alterations of the cervical cells are observed. Objective: To identify the predisposing factors for the cervical dispute in the patients treated at the María Auxiliadora Hospital during 2013 to 2017. Methods: Design study, cases, controls, analytical and observational. 216 clinical records of patients will be analyzed, divided into 72 cases and 144 controls. Results: In the bivariate analysis, significant results in early menarche (OR = 2.071, p = 0.024), the early sexual intercourse (OR = 2.213, p = 0.017), having multiple sexual partners (OR = 3.036; = 0.001) and multiparity (OR = 2.316, p = 0.005). In the multivariate analysis, the independent variables were multiple sexual partners (OR = 2.626, p = 0.003) and multiparity (OR = 2.759, p = 0.045). Conclusion: It is concluded that women with multiple sexual partners and with multiparity are at higher risk to develop cervical dysplasia. DOI:10.25176/RFMH.v19.n2.2065

Objective: To determine the factors associated with knowledge on the prevention of gastric cancer in patients attended at the external office of the Vitarte Hospital in September - November 2017. Methods: Cross-sectional, analytical and observational study. The sample consisted of 321 patients who met the selection criteria. The knowledge level test on gastric cancer prevention and the Graffar test was applied. The statistical software IBM SPSS version 23 was used to analyze the data. Results: 62% of the surveyed population obtained a medium level of knowledge. In addition, the association of the level of knowledge, work situation, access to the internet and the socioeconomic stratum was statistically significant (p = 0.019, p = 0.018, p = 0.001). Conclusion: It is concluded that the level of low and medium knowledge about gastric cancer prevention was significantly associated with having no occupation, not having access to the internet and belonging to a socioeconomic level IV and V. DOI:10.25176/RFMH.v19.n2.2064

Objective: To determine the time of illness and pre-medication as risk factors for perforated appendicitis in the Hospital of Ventanilla during the period of January - September 2017. Methods: An analytical study of type and control was carried out. The population consisted of 234 patients with their clinical histories, the group cases constituted by 78 patients with postoperative diagnosis of perforated appendicitis and the control group constituted by 156 patients with postoperative diagnosis with non-perforated appendicitis. Results: It was found that 61.5% of the patients with a disease time longer than 72 hours had perforated appendicitis (OR = 5.33, 95% CI (2.96, 9.61), p <0.001). 69.2% of patients with an out-of-hospital disease time longer than 24 hours presented perforated appendicitis (OR = 5.72, 95% CI: (3.16 - 10.37), p <0.001). 56.4% of patients with intrahospital disease time greater than 12 hours had perforated appendicitis (OR = 2.24 95% CI (1.29, 3.91) p <0.003). In relation to premedication, 15.4% of patients who took previous medications had perforated appendicitis (OR = 2.97, 95% CI (1.19, 7.39) p = 0.017). Conclusion: It is concluded that the time of illness and the premedication that in the majority of the unprescribed are risk factors for the presence ofperforated appendicitis. DOI:10.25176/RFMH.v19.n2.2071

Introduction: Diabetic foot is one of the most serious and frequent complications of diabetes mellitus, for this reason it is important to know the risk factors that trigger it. Objective: To determine the risk factors associated with diabetic foot in the PNP Luis N. Sáenz Hospital, 2017. Methods: Observational, retrospective, analytical, case and control study of 165 patients (55 cases and 110 controls) treated in the endocrinology service in 2017. Modifiable and non-modifiable risk factors associated with the development of diabetic foot were studied; the information of the clinical histories was collected through a data collection form, which was analyzed by means of the SPSS program version 25.0 using the statistical models of Chi square and the odds ratios with a level of significance less than 0.05% and a range of 95% confidence. Results: The risk factors associated with diabetic foot are disease time (p: 0.000, OR: 12.77, CI: 4.12 - 39.60); poorly controlled glycosylated hemoglobin (p: 0.029, OR: 4.55, CI: 1.17 - 17.68); Onychomycosis (p: 0.014, OR: 7.10, CI: 1.48 - 34.07); antecedent of smoking (p: 0.031, OR: 2.66, CI: 1.09 - 6.34) and chronic kidney disease (p: 0.047, OR: 3.023, CI: 1.01 - 9.0). Conclusion: We conclude that there is a statistically significant association between time of illness, poorly controlled glycosylated hemoglobin, onychomycosis, chronic kidney disease, history of smoking and developing diabetic foot. DOI:10.25176/RFMH.v19.n2.2070

Objective: To determine the clinical epidemiological indicators associated with pressure ulcers (UPP) in patients of the Medicine Service of the Hipólito Unanue National Hospital during the years 2016-2017. Methods: Observational, analytical and retrospective study, based on the review of medical records. A non-probabilistic sample was obtained for convenience, calculating the odds ratio (OR), applying the 95% confidence interval and using the chi square test, with a value of p <0.05 as statistically significant. Results: For the sample, 93 patients were obtained who fulfilled the study criteria; 50.5% were male, with an average age of 68 years (+21 years), with 74.19% of the total population being older adults. The most frequent locations of UPP were at the sacral level (77%) and heel (12.9%); likewise, the most frequent stages were: II (32.3%), IV (31.2%) and III (26.9%). The presence of severe UPP was associated to: being older (OR: 3.12, 95% CI: 1.2-8.2), hypoalbuminemia (OR: 6.23, 95% CI: 1.8-21.1), anemia (OR: 4.31, 95% CI: 1.2- 14.9) and lymphopenia (OR: 3.68, 95% CI: 1.5-9). Conclusion: Elderly patients with hypoalbuminemia, anemia or lymphopenia are at greater risk of developing severe pressure ulcers, which significantly interfere with their quality of life. DOI:10.25176/RFMH.v19.n2.2067