Sistema Regional de Información
en línea para Revistas Científicas de América Latina,
el Caribe, España y Portugal

Objetive: To determine the evolutionary clinical characteristics of the single application of calcium alginate in the treatment of second-degree burns. Methods: Observational, descriptive, quantitative study, where were included 64 patients with second degree A and B burns who attended the Fátima Clinic in Trujillo, Farmédica Clinic, and the Víctor Lazarte Echegaray Hospital (EsSALUD) were included, and were evaluated. 83 burn injuries were evaluated, pain, infection, acceptance and additional healing will be considered in each burn. Results: The burns evaluated were 44 second degree A and 39 second degree B burns, likewise, of the total patients, 60.9% were female, and 39.1% were male; the prevalent age was 30-59 years (32.8%) and by 1 to 11 years (29.7%). When applying calcium alginate, the average healing time for all patients was 16.3 days, there was mild pain in more than 97% of the cases, no case presented infection, rejection of the alginate was reported in each group . which represents 2.4%, and 2.3% required additional healing in second degree A burns and 17.9% in second degree B burns. Conclusion: Calcium alginate is an alternative for the treatment of second degree burns. , the average healing time was 16 days, no infection, no rejection of the dressing, the pain was mild in the majority of patients.

In this report, we present the case of a patient diagnosed with Evans syndrome and primary biliary cholangitis, an unusual combination that to date has few cases reported in the literature. The patient presented complex clinical characteristics, which, based on epidemiological data, was first diagnosed as dengue with alarm signs due to positive IgG results for this infection; he presented with fever, jaundice with direct predominance of hyperbilirubinemia, anemia, alkaline phosphatase and persistent elevated gamma-glutamyl transpeptidase; for which additional laboratory and imaging tests were performed to consolidate the etiology of the symptoms presented, to finally be diagnosed with both conditions.

In recent years, the great role of nutrition on general health has been demonstrated, specifically, polyphenols in relation to the treatment of metabolic and systemic diseases. Curcumin, a substance extracted from turmeric and proposed as a treatment for various diseases due to its diverse properties. The bibliographic search was done in both Spanish and English with the keywords: "curcumin", "metabolic diseases", "systemic diseases" in Pubmed, Embase and Cochrane and Scholar Google. Curcumin is a polyphenol found in turmeric, which has been shown to have antioxidant, anti-inflammatory, hepatoprotective and antidiabetic properties. Its influence has been seen in metabolic syndrome, type 2 diabetes mellitus, lupus, rheumatoid arthritis and psoriasis. Conclusions: This narrative review summarizes the influence of curcumin supplementation on various pathologies, in addition to certain general aspects.

This disease, called Sjögren's disease, is a chronic autoimmune disease characterized by the infiltration of inflammatory cells in the salivary and lacrimal glands, resulting in atrophy of acinar epithelial cells, cell death and loss of exocrine function; and women are nine times more likely than men to be affected by this condition, and systemic reactions can occur, involving practically any organ system. Pathogenesis is always difficult to achieve; but the diagnosis is based on characteristic clinical signs and symptoms and autoantibodies. This concern is what led us to carry out a review of the literature in PLOS ONE, PUBMED and GOOGLE SCHOLAR journals. The purpose of this review article is to summarize the recent literature on Sjögren's syndrome, from its pathogenesis to current treatment options.

Objetive: Determining the RAS gene as a prognostic and predictive factor in metastatic colorectal cancer. Method: This is a descriptive and retrospective study where 67 records of patients with metastatic colorectal cancer were examined, focusing on determining the RAS gene as a prognostic and predictive factor. Results: It was found that 56.7% of patients had Wild-type tumors, while 43.3% showed tumors with KRAS mutations, with no mutations detected in the NRAS gene. Both in the right and left colon, Wild-type tumors were slightly more common than tumors with KRAS mutations. Codon 12 was the most affected in 75.9% of cases of KRAS mutated tumors. Adenocarcinoma was the predominant histological type (82%), followed by mucinous adenocarcinoma (16.5%). Most patients (56.7%) were at stage IV at diagnosis. KRAS mutated tumors showed a higher tendency for recurrence and multiple metastases compared to Wild-type tumors, with the liver and lungs being the most common sites of metastasis. Differences in progression-free survival and overall survival were also observed based on the mutational status of the RAS gene, with higher progression rates in patients with KRAS mutated tumors. Conclusion: These findings suggest that mutations in the KRAS gene could be associated with a poorer prognosis in terms of disease progression and survival. Determining the status of the KRAS gene could have significant clinical implications in risk stratification and treatment planning for patients with metastatic colorectal cancer.