Sistema Regional de Información
en línea para Revistas Científicas de América Latina,
el Caribe, España y Portugal

Alzheimer's disease (AD) is currently one of the most studied dementias due to the increase of cases over the years. Acetylcholinesterase (AChE) inhibitors have been widely studied to obtain new drug candidates to combat AD. In this sense, new derivatives of the natural product 6-gingerol were planned and analyzed against the inhibition of the acetylcholinesterase enzyme in silico and its prediction on the Absorption, Distribution, Metabolism, Elimination and Toxicity (ADMET) model. Using molecular modeling tools to minimize the structures of the studied compounds and then verify the interactions of these derivatives in comparison with the standard donepezyl, due to its structural similarity, with the AChE enzyme. The results showed that two compounds have the best in silico interactions and the best ADMET properties for a good drug that can act on the Central Nervous System.

A Associação Brasileira de Odontologia Digital (ABOD) consolida-se como a maior entidade do segmento na América Latina. Os últimos anos foram de intensas transformações para toda a humanidade. A antecipação de tendências e a incorporação tecnológica nos processos de comunicação, ensino e pesquisa consolidou-se de uma forma marcante e expressiva. A ABOD está conectada a esta nova realidade. Surgimos por uma necessidade e crescemos por acreditarmos que a conexão entre profissionais de odontologia, empresas e pacientes é o nosso diferencial...

The objective of this work was to study the effectiveness of the implementation of the general law of micro and small companies (MPE), in the municipality of Barretos. The municipality regulated the General Law on Micro and Small Enterprises, through Municipal Complementary Law no. 84 of November 22, 2007, which started to regulate the right of MSEs to differentiated and favored treatment in relation to the others. Therefore, in order to investigate the proposed scope, the methodology used started by means of a bibliographic survey, then, the characterization of the municipality was carried out, through an analysis of the variables applied in the Municipal Development Index of Micro and Small Companies, the IDM-MPE, and, subsequently, the main public policy actions in support of MSEs were investigated, in order to verify what the municipality of Barretos has done to collaborate with its implementation. As a result, it was observed that the municipality did not implement public policy actions capable of promoting local development, with regard to access to credit, tax incentives, government purchases and entrepreneurial education. In the end, it was found that the general law on MSEs was not effective in the area, and the municipality should seek partnerships and more information capable of assisting it in this path to be followed.

Non-formal education occurs in spaces where there are intentional interactive processes that are collectively constructed. The non-formal spaces of environmental education (EE) are places where people can experience how the natural environment is essential for the maintenance of ecosystem relationships that guarantee the maintenance of life in all its forms. In this sense, the aim of this article is to present an experience report of an EE program, developed for students from the 6th to the 9th year of elementary school at a public school in the city of Araraquara. For the 6th grade students, an eco-pedagogical trail was programmed from the school to the spring of the Água Branca stream, and for the 7th, 8th and 9th grade students, monitored technical visits were programmed to the Fonte Luminosa Water Treatment Station, Araraquara Sewage Plant and Solid Waste Treatment Station/Acácia Recyclable Material Collectors Cooperative. The selection of these places was made in order to allow students to get to know, throughout the final years of elementary school, the entire chain of environmental sanitation of Araraquara. The monitored visits, in addition to contributing to the understanding of the technical aspects related to the sanitation chain, are configured as an important tool for reflection on the relationships established between human beings and nature and between human beings themselves, reinforcing the socio-environmental bias of EE. Works in this direction can contribute to the construction of more robust and effective EE programs, towards a transformative education.

Background: Despite the technological advances the zygomatic implants (ZI) and its proven success, this rehabilitation option is sensitive, not a routine in dental practice, requiring technical mastery, surgical experience, and in-depth anatomical knowledge, which makes it quite susceptible to complications. In addition, little is discussed about these disorders, whether immediate or late, although they are essential knowledge for the surgeons who perform this procedure. Aim: The objective of the study was to answer the question through literature review: "Are there surgical complications in zygomatic implants?" As well as to argue the main intercurrences found. Material and Methods: The review of the literature was conducted on PubMed/Medline, Cochrane and SciELO using the descriptors: “Complications” or “Failure” and “Zygomatic Implants”. The included articles were observational studies that related ZI and complications. The initial research identified 448 articles, but 42 of them that mentioned complications associated with ZI were considered in this study.  Results: The most common complication is sinusitis followed by peri-implantitis, problems with the prosthetic connection, fistula towards the implant, paresthesia, hematoma, lip laceration, ecchymosis, penetration of the orbital cavity, aspergillosis, intracranial penetration, and intraorbital hemorrhage. 44 out of 2835 ZIs placed in immediate or late loading were lost (1.5%). There were 223 minor or major complications in the 2827 implants (7.86%).  Conclusions: The low morbidity of this treatment for maxillary atrophy, there are some immediate and late complications to be considered in the choice of rehabilitation treatment and that these should be reported preoperatively to the patients. 

Peptic ulcer, gastroesophageal reflux, ulcers induced by the use of non-steroidal anti-inflammatory drugs, Zollinger-Ellison syndrome and ulcers resulting from H. pylori infection are conditions in which disorders related to gastric acid secretion occur. Patients report pain and discomfort, in addition to the observation of severe damage to the gastric mucosa that, therefore, need to be treated. Treatments are mainly based on the use of proton pump inhibitors, which include omeprazole and esomeprazole, but despite their undeniable efficacy, they have been shown to cause severe adverse reactions, especially in conditions of prolonged use. Thus, these data point to the need for effective yet safe therapeutic options, even in conditions where chronic use is required. In this context, this study aimed to present, through a systematic review of the literature, homeopathic resources that can be used to control gastric hypersecretion, mainly aiming at presenting a therapeutic alternative to patients who require the chronic use of drugs for this purpose. Homeopathic medicines such as Nux Vomica, Phosphorus, Kali Bichromicum, Lycopodium Clavatum, Carbo Veg, Hydrastis Canadensis, Graphites and Conium maculatum have been described in the literature as efficient for these pathologies. However, this work points to the need for more clinical studies, allowing the publication of original articles, which demonstrate the effectiveness of these drugs, since, considering the studied disorder, the literature is extremely scarce and quite generic, based mainly on reviews of the literature, based only on consultation on medical matters, which despite their importance, require complementation with more current studies, increasing the reliability of homeopathy both for health professionals and for patients.

The family farming has a great importance in the food production in Brazil, hoewer this sector is most often not highlighted and faces several difficulties, including the commercialization of products, mainly those of animal origin. Thus, a literature review was carried out to collect informations about the characteristics of livestock in family farming the ways of transporting animal products and the alternatives for valuing these products. The system of animal handling in the family agricultural shows its own characteristcs which depend of cultural and environment issues from each community, therefore must be considered when proposing ways to market these products.Family agricultural shows difficulties of market the animal product in the formal market mainly  due to the difficulty in meeting the legal requirements of inspection services moreover the public policies has been developing are not adjusted of the reality of the rural families. Thereby gets important to encourage the reformulation of public policies like “Selo Arte” and “geographic location” with adequacies that support the family farms and consolidate the Agroecology in Search of major appreciation by the animal products from the Family farms.

Improving the quality of life and social inclusion of the elderly population has gaps to be investigated by the Family Health Strategy team, in particular, by the Nurse. This study aimed to know and identify the existence of primary care actions that interfere in improving the quality of life and social inclusion of the elderly, as well as verifying the limits and possibilities of implementing these actions. For the present study, a bibliographic research was carried out, based on scientific publications indexed in the VHL and PubMed databases. Following the inclusion criteria, a total of 8 studies were selected for analysis, of which 87.5% (7 articles) were published in national journals and 12.5% (1 article) was published in a foreign journal. It was observed, therefore, the prevalence of the existence of prejudices and resistance in the social context in relation to the elderly, lack of knowledge of family members regarding the importance of social inclusion of the elderly and the improvement of the quality of life, lack of assistance institutions aimed at improving the quality of life. life and social inclusion of this segment of society. Since the performance of the Nurse and the primary care team has fundamental relevance in the actions of the Family Clinic, which interfere in the improvement of the quality of life of the elderly and in their social inclusion.

O estudo objetiva analisar as drogas de primeira escolha para manter a inatividade do lúpus eritematoso sistêmico (LES) na gestação e para controlar possíveis “flares” provocadas pela exacerbação hormonal no período gestacional. Consiste em uma revisão integrativa de publicações indexadas na U.S. National Library of Medicine (PUBMED), Biblioteca Virtual em Saúde (BVS) e Scientific Electronic Library Online (SCIELO). Com artigos selecionados a partir dos Descritores Controlados em Ciências da Saúde (DeCS) lúpus eritematoso sistêmico, gestação e tratamento. Constatou-se que a redução das complicações do LES na gestação está relacionada com a inatividade da doença. Esse resultado pode ser alcançado através de medicações, dentre elas a hidroxicloroquina que é uma droga segura e eficiente na prevenção de atividade de doença e deve ser utilizada durante toda a gestação. Além disso, outras medicações podem ser usadas parar tratar “flares” e outras comorbidades associadas. Esse tratamento deve ser realizado com um aconselhamento pré-natal, atendimento médico coordenado e unidade neonatal bem estruturada. Para que assim, haja um controle de doença e desfechos positivos para mãe e feto.

O termo “qualidade de vida”, embora amplamente presente na literatura, ainda é pouco discutido quando se trata de servidores públicos municipais. Assim, o objetivo desta pesquisa foi o de avaliar a percepção da qualidade de vida de profissionais vinculados a uma prefeitura de um município de pequeno porte, localizado no Vale do Jequitinhonha, em Minas Gerais. Para tanto, aplicou-se o questionário WHOQOL-Bref a 85 trabalhadores do serviço público, sendo os dados coletados analisados por meio do cálculo de escores, conforme preconizado pela Organização Mundial de Saúde. Verificou-se que a média da qualidade de vida foi de 65,5 sendo o maior escore observado no domínio social (70,1) e o menor no domínio ambiente (57,8), sendo que algumas facetas, como a insatisfação salarial e aspectos associados ao estresse avaliados como críticos.  Concluiu-se, portanto, que a qualidade de vida foi considerada boa pela maioria dos entrevistados, porém novos estudos são necessários para melhor compreender as facetas críticas do estudo e, assim, propor um plano de ações para a gestão pública municipal.