Sistema Regional de Información
en línea para Revistas Científicas de América Latina,
el Caribe, España y Portugal

Objetive: Determine the risk factors associated with preeclampsia in patients treated in the Gynecology-obstetrics service of the Regional Hospital of Ica in 2022. Material and methods: An analytical, observational, cross-sectional and retrospective study was carried out. Pregnant women with preeclampsia (Cases=91) and without preeclampsia (Controls=91) were included in the study. The data were obtained by reviewing medical records. The chi square was used, with p≤0.005, odds ratio and a 95% confidence interval. Results: Factors associated with preeclampsia were found such as: Age ≥ 35 years (p=0.014; OR=2.605; 95% CI=1.189-5.706), being single (p=0.047; OR=2.083; 1.002-4.333), without education (p=0.030; OR=2.430; 95% CI=1.072-5.507), rural origin (p=0.000; OR=3.248; 95% CI=1.692-6.236), being obese (p=0.017; OR=2.494; 95% CI=1.164-5.343), diabetes mellitus II (p=0.681; OR=1.184; 95% CI=0.528-2.654), Arterial hypertension (p=0.023; OR=3.022; 95% CI=1.125-8.120), polycystic ovary syndrome (p=0.168; OR=1.737; 95% CI=0.788-3.828), history of preeclampsia (p=0.000; OR=10.157; 95% CI=4.020-25.622), nulliparity (p=0.001; OR=2.817; 95% CI=1.544-5.140), multiple pregnancy (p=0.009; OR=3.493; 95% CI=1.317-9.265), polyhydramnios (p=0.001; OR=5.363; 95% CI=1.737). -16.555), short interpregnancy interval (p=0.000; OR=5.627; 95% CI=2.421-13.081) and gestational age less than 37 weeks (p=0.019; OR=2.120; 95% CI=1.129-3.981).  Conclusion: The presence of preeclampsia in pregnant women is associated with risk factors such as age ≥ 35 years, being single, without education, rural origin, being obese, high blood pressure, with a history of preeclampsia, nulliparity, multiple pregnancy, polyhydramnios, short interpregnancy interval and a gestational age < 37 weeks.

Sepsis is a leading cause of morbidity and mortality in critically ill patients, and its definition has evolved from the initial concept of systemic inflammatory response syndrome (SIRS) to the current one based on organ dysfunction as measured by the SOFA scale. Despite improvements in diagnosis and management, challenges persist due to variability in host response and antimicrobial resistance. This work was based on a non-systematic literature search in databases such as PubMed, ScienceDirect, Embase and MEDLINE, using key terms related to sepsis and focusing on relevant original studies and systematic reviews published between 1994 and 2024. Translational medicine has identified key biomarkers such as sTREM-1, Ang-2/Ang-1, and procalcitonin, which have demonstrated utility in early diagnosis, monitoring therapeutic response, and risk stratification in patients with sepsis. Promising therapies include PD-1/PD-L1 inhibitors, thymosin alpha 1 (Tα1), and extracellular vesicles of mesenchymal stem cells (EV-MSCs), which seek to modulate the dysregulated inflammatory response and preserve organ function. The future of sepsis management lies in the implementation of rapid diagnostic tools and personalized therapies that optimize clinical outcomes, highlighting the need for a comprehensive and multidisciplinary approach.

Inteligencia artificial y realidad extendida en la educación superior pública: un enfoque estratégico y ético para el futuro. La integración de la inteligencia artificial (IA) y la realidad extendida (RE) en la educación superior pública es un tema que ha generado gran interés en la comunidad académica¹. En este contexto, las universidades públicas se enfrentan a un desafío de gran magnitud: liderar la integración estratégica de estas herramientas mientras garantizan que su uso sea ético, inclusivo y centrado en el bienestar de las comunidades educativas².  La RE, que engloba modalidades como la realidad aumentada (RA), la realidad virtual (RV) y la realidad mixta (RM), ha ingresado al ámbito educativo con aplicaciones innovadoras que incluyen desde simulaciones inmersivas hasta laboratorios virtuales³. Estas tecnologías permiten superar limitaciones físicas y económicas, proporcionando contextos de aprendizaje enriquecidos y experiencias educativas que de otro modo serían inalcanzables4.

The case of a 53-year-old male patient, a worker and farmer, who suffered a work accident, being crushed by a concrete block, which resulted in a serious injury to his right leg, is presented. After the evaluation and diagnosis of severe neurovascular  compromise,  it  was  decided  to perform a Syme-type  amputation. Despite  initial  surgical  intervention,  the  patient  developed  postoperative wound necrosis, requiring additional transtibial surgery. The case highlights the complications associated with Syme amputation, which, although a valid option in emergency situations, can present significant postsurgical difficulties, such as infections and necrosis. This report highlights the importance of  multidisciplinary management of postoperative follow-up, monitoring of complications; It is possible to improve both the  functionality and quality of life of the patient. Future research will deal with intelligent external prostheses, with the use of artificial neural networks and electromyographic  signals, with the help of artificial intelligence (AI).

A 67-year-old female patient was admitted to the hospital emergency room, accompanied by her family member: her daughter reported that she was decompensated, was sleepy, and had difficulty responding to questioning; with a history of arterial hypertension (AHT). On clinical examination: drowsy, Glasgow: ocular opening 3, verbal response 4, motor response 5, 12/15; pupils hyper-reactive, no signs of focalization. A non-contrast computed axial tomography (CAT) scan of the head was requested, reporting that she was tomographically adequate for her age. As the hours passed, there was greater neurological compromise: confusion, disorientation, she stopped speaking, her gaze became fixed, and she progressed from superficial to deep coma. The head CT was repeated without contrast, reporting: hypodensities in the paramedian region of both thalami, without involvement of the midbrain; infarction in the Percheron artery. Interconsultation with the intensive care unit (ICU) was performed, and transfer to their service was indicated for management. The patient died the following day.

Scientific research involving students and university professors is part of the professional development process at both undergraduate and postgraduate levels, generating new knowledge that contributes to societal advancement. Throughout the scientific research process, valid sources of scientific information are consulted, aiding in the research process and the preparation of the manuscript to be disseminated, which will help advance science.To disseminate the results of scientific research, there are various means of dissemination. However, to effectively contribute to the development of science, a validation process of all the content of the work to be disseminated must be carried out. Currently, scientific journals have a validation process called "Peer Review," through which only an article that has passed this process will be published in a scientific journal. This is why institutions worldwide, where students and professors wish to register to be officially recognized as scientific researchers, require the publication of a minimum number of scientific articles in journals indexed in scientific documentation databases.The reality is that most of the time, students and university professors have not received training on the steps to follow to prepare and submit a manuscript for evaluation for publication in a scientific journal. Universities should prepare a work plan to help train the entire university community to acquire the skills needed to have their manuscripts received and accepted for evaluation for publication.

Suicidal risk in emergencies represents a critical challenge that requires a multidisciplinary approach for its identification, assessment, and management. This article reviews evidence-based strategies and tools to address this issue. Suicidal behavior is influenced by biological, psychological, and social factors, demanding comprehensive evaluations that include identifying risk and protective factors, as well as reducing access to lethal means. The approach necessitates well-defined protocols in emergency services to enhance care from admission to discharge. Validated tools such as SAFE-T, C-SSRS, and others prove useful for assessing suicidal risk. In the context of Peru, epidemiological data reveal an increase in suiciderates, with predominant methods such as hanging. The review identifies theoretical models of suicide that explain the context and contribute to understanding the complexity of suicidal phenomena. This study concludes that empathetic, interdisciplinary care, detailed clinical history documentation, and the implementation of innovative strategies in emergency settings can make a significant difference in suicide prevention, promoting a patient-centered approach adapted to local realities.

Irregular antibodies are the result of sensitization processes such as transfusions, transplants or pregnancies, and are often the cause of hemolytic reactions in transfused people. This is more critical when there is an expression of a rare phenotype in the patient, and consequently the irregular antibodies are directed against low-frequency red blood cell antigens, which makes it difficult to find donors with the same phenotype. We present the case of a patient with Systemic Lupus Erythematosus candidate for hip surgery with the presence of anti-Ku and K0 phenotype; during the search for blood units, serological compatibility was only found with a close relative, and this allowed her to schedule her surgical procedure.

Introduction: Preeclampsia is a hypertensive disorder of pregnancy with high risk of maternal-fetal morbidity and mortality. Its anesthetic management is key to optimize perioperative safety. Methodology: A narrative review was performed in databases such as PubMed, EMBASE and Cochrane Library, without time restriction, using DeCS/MeSH terms: Pre-Eclampsia, Anesthesia, Perioperative Medicine, Obstetrics, Hypertension, Pregnancy-Induced. Results: Regional anesthesia is the first choice in cesarean section due to its hemodynamic stability and lower neonatal impact. General anesthesia is reserved for cases of coagulopathy or neurological compromise, with greater risk of perioperative hypertension. Invasive monitoring, adequate use of vasopressors and multimodal analgesia are fundamental in intraoperative and postoperative management. Conclusion: A personalized anesthetic approach based on the pathophysiology of preeclampsia improves maternal-fetal outcomes. Optimization of anesthetic strategies and development of new technologies will contribute to improve safety in this population.

Introduction: Respiratory diseases such as COPD, asthma, pneumonia, and tuberculosis represent a major global public health burden and significantly impact patients' quality of life. Objective: To determine the level of quality of life in hospitalized patients with respiratory diseases in the Adult and Adolescent Clinic Service of a public hospital in San Gil, Colombia. Methods: A quantitative, descriptive, and cross-sectional study was conducted with 45 hospitalized patients diagnosed with respiratory diseases. The Saint George’s Respiratory Questionnaire and the SF-36 Quality of Life Questionnaire were used. Descriptive statistics were applied using SPSS version 24. Results: COPD was the most frequent condition, affecting 42.2% of participants. A low quality of life was observed in 68.1% of the sample. The most common symptom reported was persistent cough (40%). Most participants were male (53.3%) with a mean age of 79 years. Conclusions: Most hospitalized patients with respiratory diseases reported a low quality of life, particularly those with COPD. Strengthening comprehensive care strategies is essential to improve their functional status and overall well-being.